sp A0SXL6 EF2_CALJA Elongation factor 2 OS=Callithrix

Anti-PDGFRA Rabbit Polyclonal Antibody Cy3® VWR

PDGFRA (HGNC Symbol) Synonyms. CD140a, PDGFR2: Description. Platelet-derived growth factor receptor, alpha polypeptide (HGNC Symbol) Entrez gene summary. This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. PDGFRA has 9,009 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 93 datasets. DGIdb, The Drug Gene Interaction Database, is a research resource that can be used to search candidate genes or drugs against the known and potentially druggable genome.

Pdgfra gene

Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. PDGFRA has 9,009 functional associations with biological entities spanning 8 categories (molecular profile, organism, functional term, phrase or reference, chemical, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 93 datasets. Gene PDGFRA. PDGFRA Fusion is present in 0.09% of AACR GENIE cases, with glioblastoma, lung adenocarcinoma, breast invasive ductal carcinoma, conventional glioblastoma multiforme, and high grade ovarian serous adenocarcinoma having the greatest prevalence . Top Disease Cases with PDGFRA Fusion. Biomarker Gene name.

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GO annotations related to this gene include platelet-derived growth factor receptor binding and protein homodimerization activity . PDGFRA gene rearrangements are frequent genetic events in PDGFRA-amplified glioblastomas Gene rearrangement in the form of an intragenic deletion is the primary mechanism of oncogenic mutation of the epidermal growth factor receptor (EGFR) gene in gliomas.

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Disteche et al. (1989) and Gronwald et al. (1990) confirmed the assignment of PDGFR2 to 4q11-q12 by in situ hybridization and by Southern analysis of a Chinese hamster/human cell hybrid that retained only human chromosome 4.

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The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. 1990-04-01 · The gene represented in this entry may be involved in disease pathogenesis.

Aberrant Constitutively activating mutations in the KIT or PDGFRA receptor tyrosine Approximately 5-8% GISTs contain a mutation in PDGFRA gene ( Figure 1A). av D Chen — genesis-guided molecular classification scheme for gliomas based on the gene modules co-expressed with EGFR.
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sp A0SXL6 EF2_CALJA Elongation factor 2 OS=Callithrix

doi: 10.1016/j.ccell.2018.01.021. This plasmid is available through Addgene. XL PDGFRA BA consists of a green-labeled probe hybridizing proximal to the PDGFRA gene region at 4q12 and an orange-labeled probe hybridizing distal to the PDGFRA gene region at 4q12.

PDF CP-673451, a platelet-derived growth-factor receptor

(1989) localized the PDGFRA gene to 4q11-q12 by in situ hybridization. Disteche et al. (1989) and Gronwald et al. (1990) confirmed the assignment of PDGFR2 to 4q11-q12 by in situ hybridization and by Southern analysis of a Chinese hamster/human cell hybrid that retained only human chromosome 4. PDGFRA-associated chronic eosinophilic leukemia Genetic abnormalities that involve the PDGFRA gene cause a type of blood cell cancer called PDGFRA-associated chronic eosinophilic leukemia. This condition is characterized by an increased number of eosinophils, a type of white blood cell involved in allergic reactions. People with gastrointestinal stromal tumors (GIST) driven by a specific gene alteration have a new targeted drug option for treatment.

Platelet-derived growth factor receptor. PFS. av MS Carro · 2016 · Citerat av 17 — downloaded as Level 3 (gene level) data from TCGA (The Cancer Ge- chymal) and IDH1 (proneural), as well as amplifications of PDGFRA.